A new study indicates the taking of vitamin B3 at levels of 1,000 milligrams (500 milligrams normal and 500 designed to reach the intestines). Niacin does not have the same effect on activating NAMPT, so use niacinamide for the COVID-19 fatigue purpose.

• This helps to address fatigue issues –

• Results appeared at 2 weeks -improvement in performance and task accomplishment

• Long-term benefits noted at 6 months – less fatigue and concentration improvement

• The gut micro biome protection

• Dosage at 1,000 milligrams (500 milligrams normal and 500 designed to reach the intestines).

https://www.nature.com/articles/s42255-025-01290-1

For a healthy individual a suggested dosage has been 50 milligrams of niacinamide - 3 to 4 times daily helps restore NAD and support mitochondrial and gut micro biome function.

https://articles.mercola.com/sites/articles/archive/2025/08/21/niacinamide-covid-19-recovery.aspx?ui=8e32e92fba1165acda23a6c5258f8aed92c36438395663bfbc8591dbe2cfe43f&sd=20201022&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20250821_HL2&foDate=false&mid=DM1796196&rid=369860887

Vitamin B3

Vitamin B3 or Niacin, often in the non-flush form of niacinamide, has been known for its effectiveness in treating some of the symptoms of drug or alcohol addiction or lifestyle. 

• The use of doses of up to 6,000 mg a day has been used to treat severe addiction symptoms.

• The severe symptoms often associated with pellagra are dermatitis, insomnia, depression, memory loss, peripheral neuritis, dementia, and diarrhea.

• The presence of tryptophan plays a role in the liver producing niacin. The reduction of niacin results in decreased NAD and NADP which in turn reduces our metabolism of protein, fat, and carbohydrates.

• It also shows up in regions that used corn, which binds with niacin’s decreasing bioavailability, as a basis for their main vegetable or grain. https://ejim.springeropen.com/articles/10.1186/s43162-020-00031-y; https://www.ncbi.nlm.nih.gov/books/NBK557728/

Niacinamide Also

·         Prevents Kidney Disease through NAD+ increase or lack of breakdown

·         Countering Leaky Gut caused by toxins such as glyphosate and gluten

·         Countering Heart Failure

https://articles.mercola.com/sites/articles/archive/2025/08/21/niacinamide-covid-19-recovery.aspx?ui=8e32e92fba1165acda23a6c5258f8aed92c36438395663bfbc8591dbe2cfe43f&sd=20201022&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20250821_HL2&foDate=false&mid=DM1796196&rid=369860887

 B Complex

When taking supplement B3 it should be taken with either a B complex or multivitamin with the equivalent of a B complex. There is always a synergy between the different vitamins and minerals for the body to effectively balance and heal.

https://articles.mercola.com/sites/articles/archive/2025/08/21/niacinamide-covid-19-recovery.aspx?ui=8e32e92fba1165acda23a6c5258f8aed92c36438395663bfbc8591dbe2cfe43f&sd=20201022&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20250821_HL2&foDate=false&mid=DM1796196&rid=369860887

Vitamin B3 in either the form of niacin or niacinamide has various effects upon the human body and can be used according to the function or effect needed.